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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: Anaplastic lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLC), and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors (ALK-TKIs). However, the clinical efficacy is highly variable. Pre-existing intratumoral heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targeted therapies. In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targeted therapy efficacy. Through the application of next-generation sequencing (NGS), 7.2% (326/4548) of patients were detected to be ALK positive. On the basis of the adjusted VAF (adjVAF, VAF normalization for tumor purity) of four different threshold values (adjVAF < 50%, 40%, 30%, or 20%), the association of ALK subclonality with crizotinib efficacy was assessed. Nonetheless, no statistical association was observed between median progression-free survival (PFS) and ALK subclonality assessed by adjVAF, and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib. Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

Keywords： ALK fusion next-generation sequencing fluorescence in situ hybridization immunohistochemistry

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Short-term effect of temperature variation on the competition between PAOs and GAOs during acclimation period of an EBPR system

Nanqi REN, Han KANG, Xiuheng WANG, Nan LI

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 2, Pages 277-282 doi: 10.1007/s11783-010-0226-x

Abstract: PAOs and GAOs were analyzed by fluorescent in situ hybridization (FISH), and intracellular polyphosphate

Keywords： fluorescent in situ hybridization (FISH) tetrad forming organisms (TFOs) temperature variation enhanced

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Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization Article

Kengo Kubota, Kei Igarashi, Masayoshi Yamada, Yasuyuki Takemura, Yu-You Li, Hideki Harada

Engineering 2022, Volume 9, Issue 2, Pages 61-66 doi: 10.1016/j.eng.2021.05.012

Abstract: anaerobic sludge blanket reactor treating phenolic wastewater was investigated using fluorescence in situhybridization (FISH) and clone library construction.

Keywords： Cryptanaerobacter Fluorescence in situ hybridization Anaerobic phenol degradation Syntrophorhabdaceae

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Comments on “Determination of heterozygosity for avirulence/virulence loci through sexual hybridization

Ralf T. Voegele

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1, Pages 121-122 doi: 10.15302/J-FASE-2017142

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Determination of heterozygosity for avirulence/virulence loci through sexual hybridization of

Yuan TIAN,Gangming ZHAN,Xia LU,Jie ZHAO,Lili HUANG,Zhensheng KANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1, Pages 48-58 doi: 10.15302/J-FASE-2016114

Abstract: Wheat stripe rust caused by f. sp. is one of the most devastating diseases of wheat worldwide and resistant cultivars are vital for its management. Therefore, investigating the heterozygosity of the pathogen is important because of rapid virulence changes in isolates heterozygous for avirulence/virulence. An isolate of f. sp. was selfed on to determine the heterozygosity for avirulence/virulence loci. One hundred and twenty progeny isolates obtained from this selfing were phenotyped using 25 lines of wheat containing genes and genotyped with 96 simple sequencing repeat markers, with 51 pathotypes and 55 multi-locus genotypes being identified. All of these were avirulent on lines with , , , and and virulent on lines with , and , indicating that the parental isolate was homozygously avirulent or homozygously virulent for these loci. Segregation was found for wheat lines with , , , , , , , , , , , , , , , and . The 17 cultivars to which the was identified as heterozygous with respect to virulence/avirulence should not be given priority in breeding programs to obtain new resistant cultivars.

Keywords： Puccinia striiformis f. sp. tritici selfing heterozygosity virulence inheritance

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Short-term effects of excessive anaerobic reaction time on anaerobic metabolism of denitrifying polyphosphate- accumulating organisms linked to phosphorus removal and N

Gang GUO, Yayi WANG, Chong WANG, Hong WANG, Mianli PAN, Shaowei CHEN

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 4, Pages 616-624 doi: 10.1007/s11783-013-0505-4

Abstract: The fluorescence in situ hybridization (FISH) analysis revealed that the sludge was mainly dominated

Keywords： removal anaerobic reaction time nitrous oxide polyhydroxyalkanoate free nitrous acid fluorescence in-situhybridization

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Effect of fiber hybridization on energy absorption and synergy in concrete

Ahmadreza RAMEZANI, Mohammad Reza ESFAHANI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 6, Pages 1338-1349 doi: 10.1007/s17009-019-0558-2

Abstract: main concentration being on energy absorption characteristics of concrete and the efficacy of fiber hybridization

Keywords： hybrid fiber-reinforced concrete synergy toughness steel fibers polypropylene fibers

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Development and application of ex-situ presulfurization technology for hydrotreating catalysts in China

Yulan GAO, Xiangchen FANG, Zhenmin CHENG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3, Pages 287-296 doi: 10.1007/s11705-010-0529-2

Abstract: The development and application of ex-situ presulfurization (EPRES) technology for hydrotreating catalysts

Keywords： ex-situ presulfurization in situ presulfurization hydrotreating catalyst sulfur utilization ratio

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Polyolefin-nanocomposites with special properties by in-situ polymerization

Walter Kaminsky

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3, Pages 555-563 doi: 10.1007/s11705-018-1715-x

Abstract:

Exceptionally strong polyolefin nanocomposites are synthesized by in-situ polymerization using

Keywords： polyolefin nanocomposites metallocenes methylaluminoxane

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Propagation characteristics of transient waves in low-strain integrity testing on cast-in-situ concrete

Hanlong LIU, Xuanming DING

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 2, Pages 240-240 doi: 10.1007/s11709-009-0100-8

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Thermodynamic analysis of liquid phase in situ hydrogenation of glycerol for 1,3-propanediol synthesis

Kun OUYANG, Yu HUANG, Haoyi CHEN, Tao LI, Fahai CAO, Dingye FANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1, Pages 67-73 doi: 10.1007/s11705-010-0541-6

Abstract: reforming (APR) and catalytic hydrogenation of glycerol, a novel reaction system of liquid phase in situreforming reaction; the hydrogen generated from the APR of glycerol can be quickly transformed to the in situ

Keywords： glycerol aqueous-phase reforming 1 3-propanediol in-situ reduction

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In situ-based assessment of soil liquefaction potential–Case study of an earth dam in Tunisia

Ikram GUETTAYA,Mohamed Ridha EL OUNI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4, Pages 456-461 doi: 10.1007/s11709-014-0259-5

Abstract: The present paper examines the evaluation of liquefaction potential of an earth dam foundation in Tunisia. The assessment of soil liquefaction was made using deterministic and probabilistic simplified procedures developed from several case histories. The data collected from the field investigation performed before and after the vibrocompaction are analyzed and the results are reported. The obtained results show that after vibrocompaction, a significant improvement of the soil resistance reduces the liquefaction potential of the sandy foundation. Indeed, in the untreated layers, the factor of safety drops below 1 which means that the soil is susceptible for liquefaction. However, in the compacted horizons, the values of exceed the unit which justifies the absence of liquefaction hazard of the foundation.

Keywords： liquefaction cone penetration test (CPT) standard penetration test (SPT) vibrcompaction sand

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In situ synthesis of FeS/Carbon fibers for the effective removal of Cr(VI) in aqueous solution

Rongrong Zhang, Daohao Li, Jin Sun, Yuqian Cui, Yuanyuan Sun

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1247-8

Abstract: Abstract • FeS/carbon fibers were in situ synthesized with Fe-carrageenan hydrogel fiber. • The doubleTherefore, this study investigates in situ synthesized FeS/carbon fibers with an Fe-carrageenan biomass

Keywords： Carrageenan FeS Double-helix structure Hexavalent chromium

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In-situ condition monitoring of reinforced concrete structures

Sanjeev Kumar VERMA,Sudhir Singh BHADAURIA,Saleem AKHTAR

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 4, Pages 420-437 doi: 10.1007/s11709-016-0336-z

Abstract: deterioration mechanisms, performance characteristics and parameters and condition monitoring of in situ

Keywords： concrete carbonation chloride corrosion monitoring models

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Phase problems in optical imaging Review

Guo-hai SITU, Hai-chao WANG

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 9, Pages 1277-1287 doi: 10.1631/FITEE.1700298

Abstract: Because the phase contains more information about the fieldcompared to the amplitude, measurement of the phase is encounteredin many branches of modern science and engineering. Direct measurementof the phase is difficult in the visible regime of the electromagneticwave. One must employ computational techniques to calculate the phasefrom the captured intensity. In this paper, we provide a review ofour recent work on iterative phase retrieval techniques and theirapplications in optical imaging.

Keywords： Phase retrieval Phase imaging Computational imaging Gerchberg-Saxton algorithm Optical encryption Computer-generated hologram

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Title Author Date Type Operation

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Journal Article

Short-term effect of temperature variation on the competition between PAOs and GAOs during acclimation period of an EBPR system

Nanqi REN, Han KANG, Xiuheng WANG, Nan LI

Journal Article

Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization

Kengo Kubota, Kei Igarashi, Masayoshi Yamada, Yasuyuki Takemura, Yu-You Li, Hideki Harada

Journal Article

Comments on “Determination of heterozygosity for avirulence/virulence loci through sexual hybridization

Ralf T. Voegele

Journal Article

Determination of heterozygosity for avirulence/virulence loci through sexual hybridization of

Yuan TIAN,Gangming ZHAN,Xia LU,Jie ZHAO,Lili HUANG,Zhensheng KANG

Journal Article

Short-term effects of excessive anaerobic reaction time on anaerobic metabolism of denitrifying polyphosphate- accumulating organisms linked to phosphorus removal and N

Gang GUO, Yayi WANG, Chong WANG, Hong WANG, Mianli PAN, Shaowei CHEN

Journal Article

Effect of fiber hybridization on energy absorption and synergy in concrete

Ahmadreza RAMEZANI, Mohammad Reza ESFAHANI

Journal Article

Development and application of ex-situ presulfurization technology for hydrotreating catalysts in China

Yulan GAO, Xiangchen FANG, Zhenmin CHENG

Journal Article

Polyolefin-nanocomposites with special properties by in-situ polymerization

Walter Kaminsky

Journal Article

Propagation characteristics of transient waves in low-strain integrity testing on cast-in-situ concrete